METHOD FOR PREPARING N-COMPLEXES OF DICHLORODI-[(4-(BENZYLSULFANYL)METHYL)-3,5-DIMETHYL-1H-PYRAZOLE]PALLADIUM (II) AND PLATINUM (II) Russian patent published in 2018 - IPC C07F15/00 A61K31/555 

Abstract RU 2672265 C2

FIELD: chemistry.

SUBSTANCE: invention relates to chemistry of coordination compounds, in particular to a method for preparing sulfur-containing N-complexes of dichlorodi-[(4-(benzylsulfanyl)methyl)-3,5-dimethyl-1H-pyrazole]palladium (II) or platinum (II) of general formula (1):

(1) X=Pd or Pt. Method comprises reacting the bidentate reagent of 4-[(benzylsulfanyl)methyl]-3,5-dimethyl-1H-pyrazole with palladium (II) chloride, in a medium of acetonitrile or potassium tetrachloroplatinate in a water-acetone medium at a molar ratio of 4-[(benzylsulfanyl)methyl]-3,5-dimethyl-1H-pyrazole : palladium (II) chloride or potassium tetrachloroplatinate, equal to 2:1, at a temperature of 15–25 °C and atmospheric pressure for 3–5 hours.

EFFECT: obtained compounds can be used as biologically active substances with anti-cancer activity.

1 cl, 1 tbl, 2 ex

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RU 2 672 265 C2

Authors

Akhmetova Vnira Rakhimovna

Akhmadiev Nail Salavatovich

Tulyabaev Artur Radisovich

Khisamutdinov Ravil Akhmetzyanovich

Ibragimov Askhat Gabdrakhmanovich

Dzhemilev Usein Memetovich

Dates

2018-11-13Published

2017-01-27Filed