PYRAZOLOTRIAZINE AND/OR PYRAZOLOPYRIMIDINE DERIVATIVES AS A SELECTIVE CYCLIN-DEPENDENT KINASE INHIBITOR Russian patent published in 2023 - IPC C07D487/04 C07D519/00 A61K31/519 A61K31/53 A61P31/00 A61P29/00 A61P35/00 A61P37/00 

FIELD: agriculture.

SUBSTANCE: invention relates to derivatives of pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine, specifically to a compound of general formula I or enantiomer, stereoisomeric form, mixture of enantiomers, diastereomer, mixture of diastereomers, a racemate of the compounds and a pharmaceutically acceptable salt. The values of X, Q, L¹, R¹, R² and Z are defined in the claims. A pharmaceutical composition containing the specified compound and the use of the compound are also proposed.

EFFECT: proposed compound of formula I has inhibitory activity against cyclin-dependent kinase 7 (CDK7) and can be used for the prevention and/or treatment of proliferative diseases.

14 cl, 1 dwg, 11 tbl, 5 ex