GPR40 AGONISTS Russian patent published in 2017 - IPC C07C251/48 C07C251/52 C07C255/41 C07C255/61 C07C257/06 C07C317/32 C07D261/08 C07D307/79 C07D333/58 C07F9/40 A61K31/15 A61K31/343 A61K31/381 A61K31/42 A61P9/00 C07D213/64 C07D213/74 A61K31/4402 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of formula (I), wherein ring A is an optionally substituted phenyl group, wherein the optional substituent is fluorine or methoxy; ring B is an optionally substituted phenyl group, wherein the optional substituent is selected from methoxy, 1 or 2 fluorine atoms, -CH₂CN, -O-CH₂-C₃cycloalkyl, isopropoxy; isoxazole (which may be substituted with 1 or 2 methyl groups), -O-CH₂-CN and -O-CH₂-C(O)OH; X is a bond or -CH₂O-; Y is -CH₂O-; Z is a bond or -(CR⁵R⁶)-; L is -CO₂H; R¹ is OR⁷; R² is a ring, selected from the group consisting of C₃-C₁₂ cycloalkyl, C₆aryl-condensedC₃-C₆ cycloalkyl, and optionally substituted C₆ aryl, each possible substituent being selected from methyl, fluoro, methoxy, cyano and methanesulfonyl; each R³, R⁴, R⁵ and R⁶ is independently selected from the group consisting of H, CN, OH, CONH₂, C₁-C₁₂ alkyl, C₂-C₁₂ alkynyl, C₆ aryl and optionally substituted C₁-C₁₈ heteroaryl selected from isoxazole, wherein the isoxazole may be substituted with 1 or 2 methyl groups, or any two of R³, R⁴, R⁵ and R⁶ together with the atoms to which they are attached, can form an optionally substituted C₃ cycloalkyl or a double bond between the atoms to which they are attached; R⁷ is selected from the group consisting of H, optionally substituted C₁-C₁₂ alkyl, where possible substituents are selected from 3 fluorine atoms or -N(CH₃)₂ or phenyl, C₂-C₁₂ alkenyl, C₃-C₁₂ cycloalkyl and C₆ aryl; r is 1; or a pharmaceutically acceptable salt thereof. The compounds of formula (I) of the invention are intended for manufacture of a pharmaceutical composition or a medicament for diabetes treatment.

EFFECT: GPR40 activating connections.

30 cl, 3 tbl, 124 ex