FIELD: chemistry.
SUBSTANCE: invention relates to 1,2,4-triazolo[4,3-a]pyridine compounds of formula (I) as positive allosteric modulators (PAM) of metabotropic glutamate receptors of subtype 2 ("mGluR2"), as well as to a pharmaceutical composition based thereon. In general formula (I) R1 is selected from (C3-8cycloalkyl)C1-3alkyl and (C1-3alkyloxy)C1-3alkyl.
(I).
EFFECT: invention relates to a method of treating or preventing disorders of the central nervous system, such as schizophrenia, migraine, epilepsy, panic disorder, and so forth.
8 cl, 9 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 3-AZABICYCLO[3,1,0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | 2009 |
|
RU2510396C2 |
| 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZINE-4(5H)-ONE COMPOUNDS AND USE THEREOF AS NEGATIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS | 2015 |
|
RU2708391C2 |
| 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZINE-4(5H)-ONE COMPOUNDS AND USE THEREOF AS NEGATIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS | 2015 |
|
RU2711382C2 |
| INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS | 2009 |
|
RU2517181C2 |
| 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND USE THEREOF AS NEGATIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS | 2015 |
|
RU2696135C2 |
| INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | 2009 |
|
RU2512283C2 |
| INHIBITORS OF PHOSPHODIESTERASE 10 ENZYME | 2013 |
|
RU2667058C2 |
| COMBINATIONS COMPRISING PDE 2 INHIBITORS SUCH AS 1-ARYL-4-METHYL- [1,2,4]TRIAZOLO[4,3-A]QUINOXALINE COMPOUNDS AND PDE 10 INHIBITORS FOR USE IN TREATMENT OF NEUROLOGICAL OR METABOLIC DISORDERS | 2013 |
|
RU2657540C2 |
| CHROMON OXIME NEW DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS | 2015 |
|
RU2672569C2 |
| SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONE, PREPARING AND USING THEM | 2010 |
|
RU2543384C2 |
