3-AZABICYCLO[3,1,0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Russian patent published in 2014 - IPC C07D401/04 A61K31/4412 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds, particularly novel pyridinone derivatives of formula (I) or stereochemically isomeric forms thereof, where R¹ is C_1-6alkyl or C_1-3alkyl, substituted with C_3-7cycloalkyl; R² is a halogen, trifluoromethyl, C_1-3alkyl or cyclopropyl; X is a covalent bond, O or O-CH₂; Ar is an unsubstituted phenyl or phenyl substituted with n radicals R⁴, where n equals 1, 2 or 3; where each R⁴ is a halogen; or pharmaceutically acceptable addition salts or solvates thereof. The invention also relates to a pharmaceutical composition, having the activity of positive allosteric modulators of the metabotropic glutamate receptor subtype 2, based on compounds of formula I and use of compounds of formula I to prepare a medicinal agent for treating or preventing neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved.

EFFECT: novel compounds which can be useful in treating and preventing neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved are obtained and described.

15 cl, 4 ex, 1 tbl