METHOD OF PREPARING COMPOUND Russian patent published in 2018 - IPC C07D471/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a process for the preparation of (R)-5-bromo-4-(3-amino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1H-pyrrolo[2,3-b]pyridine of Formula (I): (I) or a pharmaceutically acceptable salt thereof, comprising reacting a compound of Formula (II): (II), wherein X is halogen, with a compound of Formula (III): (III), where R is an amino protecting group, to give a compound of Formula (IV): (IV), nitro-reduction reaction of the compound of Formula (IV) to obtain a compound of Formula (V): (V), reacting a compound of Formula (V) with a compound of Formula (VI): (VI), where R¹ is selected from the group consisting of chlorine, fluorine, bromine and OR², where R² is selected from the group consisting of cyclopropylcarbonyl, isobutylcarbonyl, isopropylcarbonyl, ethylcarbonyl, methylcarbonyl, 2-pyridyl and N-succinimidyl to give the compound of Formula (VII): (VII) step of deprotecting R in the compound of Formula (VII) with pouring (R)-5-bromo-4-(3-(amino)piperidin-1-yl)-3-(cyclopropanecarboxamido)-1H-pyrrolo[2,3-b]pyridine of Formula (I).

EFFECT: method of preparing a compound is provided.

20 cl, 2 ex