METHOD OF PHOTODYNAMIC THERAPY WITH EFFICIENCY CONTROL IN REAL TIME MODE Russian patent published in 2018 - IPC A61N5/67 A61B6/08 A61K38/41 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology and radiation therapy, and can be used for photodynamic therapy with real-time control of efficacy. For that the delivery of the photosensitizer to the tumor cells is performed. Tetrapyrrole dye tetra(aryl)tetracyanoporphyrazine of the general formula is used as a photosensitizer:

,

where R is the expander, R=2-MeOPh (2-methoxyphenyl), or 4-MeOPh (4-methoxyphenyl), or 4-EtO-3-MeOPh (3-methoxy-4-phenetyl), or 3-C2H3Ph (3-vinylphenyl), or Phen (9-phenanthryl), or Et2NPh (4-diethylaminophenyl), or 4-C3H3OPh (4-(2-propynyloxy)phenyl), or 4-C3H3O-3-MeOPh (3-methoxy-4-(2-propynyloxy)phenyl), or 4-C3H3O-3-EtOPh (4-(2-propynyloxy)-3-phenetyl), or 4-BnO-3-MeOPh (3-methoxy-4-benzyloxyphenyl), or 4-BnO-EtOPh (4-benzyloxy-3-phenetyl), or 4-FBnO-3-MeOPh (3-methoxy-4-fluorobenzyloxyphenyl), or 4-FBnO-3-EtOPh (4-fluorobenzyloxy-3-ethoxyphenyl), or 4-BnOPh (4-benzyloxyphenyl), or 4-BrBnO-3-MeOPh (4-(benzyloxy)-3-methoxyphenyl), or 4-FPh (4-fluorophenyl), or 4-FBnOPh (4-fluorobenzyloxyphenyl), or 4-BrBnOPh (4-bromobenzyloxyphenyl). Next, fluorescence visualization of the tumor is performed and the lifetime of the excited state of the photosensitizer is determined when the maximum accumulation in the tumor is reached. Photodynamic destruction of the identified pathological focus is performed by fractionated stepwise irradiation with a central wavelength coinciding with the absorption spectrum of the photosensitizer. In this case, in the intervals between the stages of irradiation, the lifetime of the excited state of the photosensitizer is estimated. Procedure of photodynamic irradiation is repeated until the lifetime of the excited state of the photosensitizer is increased by 1.5–2 times relative to the initial level.

EFFECT: method provides an increase in the probability of the pathological formation complete removal in one session of photodynamic therapy while minimizing the negative impact on healthy tissues due to the individualization of the mode of photodynamic therapy using photosensitizers with the properties of viscous sensors.

6 cl, 2 tbl, 2 ex, 13 dwg