METHOD OF PHOTODYNAMIC THERAPY Russian patent published in 2015 - IPC A61N5/67 

FIELD: medicine.

SUBSTANCE: introduction of a photosensitiser and exposure to low intensive laser irradiation are realised. After carrying out photodynamic therapy (PDT) spectral-fluorescent diagnostics is performed and a degree of the medication burning out is determined. If the ratio of the tumour/norm is higher than 1.0, the absence of burning out is diagnosed. If the ratio of the tumour/norm is 0.8-1.0, partial burning out is diagnosed. If the ratio of the tumour/norm is lower than 0.8, complete burning out is diagnosed. In case of partial burning out or the absence of burning out PDT procedure is continued additionally with the power density of 0.35 W/cm² by a step-by-step supply of 50 J/cm² with the evaluation of a degree of burning out after each step. When complete burning out is registered, PDT procedure is finished.

EFFECT: increased efficiency of the photodynamic therapy due to objective monitoring of the performed treatment, selection of individual doses of the laser influence on the basis of fluorescence parameters, which makes it possible to obtain the full response of the tumour to the treatment and reduce side effects and the number of recurrences.

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