FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a method for predicting an effective dose of 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof for a patient with myelodysplastic syndrome. Invention also relates to a method for predicting the susceptibility of said patient to treatment with 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof. In addition, the invention relates to a method for determining the amount of xanthosine monophosphate in whole blood for use in the methods of the invention. Among other things, the invention relates to a kit for predicting an effective dose of 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof for said patient; and a kit for predicting the susceptibility of said patient to treatment with 5-hydroxy-1H-imidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
EFFECT: invention makes it possible to distinguish quantitatively impurities and xanthosine monophosphate in whole blood.
24 cl, 19 tbl, 8 dwg
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