NEUROGENESIS-STIMULATING ISOQUINOLINE DERIVATIVES Russian patent published in 2018 - IPC A61K31/472 A61K31/4725 C07D217/26 C07D401/04 C07D401/06 C07D401/12 C07D405/04 C07D405/12 C07D417/06 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the use of compounds of general formula I in which R¹ is phenyl or pyridinyl which is optionally substituted with halogen, cyano or C_1-4-alkyl substituted with halogen, or is dihydro-pyran-4-yl; R² is hydrogen or C_1-4-alkyl; R³ is -(CHR)_n-phenyl, optionally substituted with C_1-4-alkoxy or S(O)₂-C_1-4-alkyl, or is a five-membered heterocycloalkyl containing one heteroatom selected from O, or is -(CH₂)_n-five- or six-membered heteroaryl containing one to two heteroatoms selected from N, optionally substituted with C_1-4-alkyl, or is hydrogen, C_1-4-alkyl, C_1-4-alkyl substituted with halogen, C_1-4-alkyl substituted with hydroxyl, -NR-S(O)₂-C_1-4-alkyl, - (CH₂)_n-C_3-7cycloalkyl or -(CH₂)_n-S(O)₂-C_1-4-alkyl; or R² and R³ form, together with the nitrogen atom to which they are attached, a heterocycloalkyl ring selected from the group consisting of 1,1-dioxo-thiomorpholinyl, morpholinyl or pyrrolidinyl substituted with hydroxyl; R is hydrogen or C_1-4-alkyl; n is 0, 1 or 2; or their pharmaceutically acceptable acid addition salts for the treatment of diseases in which it is useful to stimulate neurogenesis from neural stem cells, including Parkinson's disease, hearing loss, lateral amyotrophic sclerosis, and Huntington's disease. Invention also relates to the use of compounds selected from the group for the treatment of diseases, in which it is useful to stimulate neurogenesis from neural stem cells, to a compound selected from the group, to a compound of formula I, to a pharmaceutical composition. .

EFFECT: disclosed is the use of compounds of general formula I for the treatment of diseases in which the stimulation of neurogenesis from neural stem cells is useful.

11 cl, 2 tbl, 34 ex