FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof. In formula (I), A is phenyl, a 5-6 membered heteroaryl containing from 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, or a 9-membered bicyclic heteroaryl containing one heteroatom selected from nitrogen and oxygen; B is phenyl, indanyl, a 5-6 membered heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, or a 9-11 membered bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from a group consisting of nitrogen and oxygen; L is independently selected from the group consisting of a chemical bond, oxygen, sulfur, -NR4-, -(CRCRD)t-, -O(CRCRD)t-, -(CRCRD)tO-, -N(R4)(CRCRD)tO- and -O(CRCRD)tN(R4)-; X is independently selected from the group consisting of -CH2-, oxygen and NH; the meanings of the remaining radicals are indicated in the claims. Also the invention relates to individual compounds, to the use of the compound, to a method for treating a condition or disorder mediated by antagonistic activity towards the TRPM8 receptor, to a pharmaceutical composition, to a method for producing a pharmaceutical composition.
.
EFFECT: new compounds with TRPM8 receptor antagonist activity are obtained.
12 cl, 44 tbl, 591 ex
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