ANTIFUNGAL COMPOSITION OF EUTECTIC TYPE (OPTIONS) Russian patent published in 2018 - IPC A61K9/00 A61K31/00 A61P31/10 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, namely to clinical pharmacology, and is intended for the preparation of combined antifungal agents. Antifungal composition of the eutectic type contains a binary eutectic combination, corresponding to the composition of double eutectic ±2 mol %, selected from: Clotrimazole:Terbinafine 71:29 % mol %, Clotrimazole:Nifuratelum 78:22 % mol %, Clotrimazole:Fluconazole 44:56 mol %, Ketoconazole:Fluconazole 34:66 mol %, Ketoconazole:Terbinafinum 70:30 mol %, Itraconazole:Ketoconazole 36:64 mol %, Itraconazole:Clotrimazole 35:65 mol %, Itraconazole:Fluconazole 20:80 % mol %, Itraconazole:Terbinafinum 72:28 mol %, Itraconazole:Niferatelum 64:36 mol %, Fluconazole:Terbinafinum 60:40 mol %, Itraconazole:Diclofenac 40:60 mol %, Clotrimazole:Diclofenac 50:50 mol %, Fluconazole:Diclofenac 54:46 mol %, Clotrimazole:Nitroxoline 62:38 mol %, Clotrimazole:Anaesthesinum 31:69 mol %, Clotrimazole:Tinidazole 46:54 mol %, Fluconazole:Tinidazole 42:58 mol %.

EFFECT: use of the invention provides for obtaining antifungal compositions of the eutectic type, with increased antifungal effect, reduced rate of formation of resistance to them and increased activity to strains with already formed resistance.

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