FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of formula 1 or to its pharmaceutically acceptable salt, where A is a benzene ring, or a pyridine ring, X is a CO, or CHOH, R1 represents hydrogen, or C1-4 hydroxyalkyl, R2 represents phenyl, pyrazolyl, pyridin-2-onyl, pyrrolidinyl or thiazolyl, where R2 is unsubstituted or substituted by one or two substituents, each of which is independently selected from the group including C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, halo and cyano, and R3 represents hydrogen, or C1-4 alkyl. Invention also relates to a pharmaceutical composition based on a compound of formula 1, intermediate compounds of formulas 16 and 21, as well as to methods for producing intermediate compounds. 
Formula 1 
Formula 16 
Formula 21.
EFFECT: new heterocyclic compounds are obtained useful for prevention or treatment of diseases caused by abnormal activity of PRS (prolyl tRNA synthetase).
15 cl, 2 tbl, 65 ex
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