FIELD: medicine.
SUBSTANCE: invention relates to medicine and is an analgesic agent, including a substituted 2,2'-[(6-methylpyrimidine-2,4-diyl)bis(3-phenyl-1H-1,2,4-triazol-1,5-diyl)]dipropanoic acid (I), selected from group: Ia – 2,2'-[(6-methylpyrimidine-2,4-diyl)bis(3-(4-nitrophenyl)-1H-1,2,4-triazol-1,5-diyl)]dipropanoic acid; Ib – 2,2'-[(6-methylpyrimidine-2,4-diyl)bis(3-(4-methoxyphenyl)-1H-1,2,4-triazol-1,5-diyl)]dipropanoic acid; Iv – 2,2'-[(6-methylpyrimidine-2,4-diyl)bis(3-(4-methylphenyl)-1H-1,2,4-triazol-1,5-diyl)]dipropanoic acid; Ig – 2,2'-[(6-methylpyrimidine-2,4-diyl)bis(3-phenyl-1H-1,2,4-triazol-1,5-diyl)]dipropanoic acid, – as an active substance.
EFFECT: implementation of the invention allows to obtain an analgesic with low toxicity, that exhibits a significantly greater analgesic activity than the comparator drugs widely used in medicine.
1 cl, 4 ex, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANALGESIC AND ANTIVIRAL AGENT BASED ON 2,2'-[(6-METHYLPYRIMIDINE-2,4-DIYL)BIS(3-(4-NITROPHENYL)-1H-1,2,4-TRIAZOLE-1,5-DIYL)]DIPROPANOIC ACID | 2017 |
|
RU2672878C1 |
| ANALGESIC AGENT BASED ON SUBSTITUTED 2-[1-(1H-BENZIMIDAZOL-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOL-5-YL]PROPANOIC ACID | 2017 |
|
RU2661603C1 |
| SUBSTITUTED 2,2'-[(6-METHYLPYRIMIDINE-2,4-DIYL)BIS(3-PHENYL-1N-1,2,4-TRIAZOL-1,5-DIYL)]DIPROPANIC ACIDS AND METHOD OF THEIR PRODUCTION | 2016 |
|
RU2631325C1 |
| ANALGESING AND ANTIVIRAL AGENT BASED ON SUBSTITUTED 2-[1-(1H-BENZIMIDAZOL-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOLE-5-YL]PROPANE ACID | 2018 |
|
RU2684781C1 |
| SUBSTITUTED DERIVATIVES OF AZOLONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING | 1994 |
|
RU2128659C1 |
| DERIVATIVE OF DI- AND TRIAZOLYLPROPANE, METHODS OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1996 |
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RU2145605C1 |
| HARMFUL FUNGI CONTROL AGENT AND METHOD | 1996 |
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RU2158083C1 |
| 2-(PHENYL OR PYRID-3-YL)AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATING KINASE 2 (LRRK2) FOR TREATMENT OF PARKINSON'S DISEASE | 2012 |
|
RU2647849C2 |
| SUBSTITUTED 2-(1,3-BENZOTHIAZOL-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOL-5-YL) PROPANOIC ACIDS AND SYNTHESIS METHOD THEREOF | 2015 |
|
RU2603958C1 |
| SELECTIVE ANTITUBERCULOUS AGENTS REPRESENTING SUBSTITUTED 7-ARYL(HETERYL)-6-CARBETHOXY-4,7-DIHYDRO-1,2,4-TRIAZOLE[1,5-a]PYRIMIDINES OR SUBSTITUTED 7-ARYL(HETERYL)-4,7-DIHYDRO-6-NITRO-1,2,4-TRIAZOLE[1,5-a]PYRIMIDINES OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION THEREOF AND METHOD FOR PREPARATION OF SUBSTITUTED 7-ARYL(HETERYL)-6-CARBETHOXY-5-METHYL-4,7-DIHYDRO-1,2,4-TRIAZOLE[1,5-a]PYRIMIDINES | 2007 |
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RU2360905C2 |
