FIELD: chemistry.
SUBSTANCE: present invention relates to para-aminobenzyl-linker compounds of formula (I), where R1, R2, A1, A2, X are defined in the claims, intended for binding portions of a drug with antibodies, to linker-drug compounds, in which said para-aminobenzyl-linker compounds are covalently bonded to portions of the drug, and to antibody-drug conjugates containing said para-aminobenzyl-linker compounds, covalently bonded to the drug, wherein said drug is enzymatically cleaved from the conjugate in a specific type of cells or tissues that are targets for said antibody.
EFFECT: disclosed are para-aminobenzyl linkers, a method for production thereof and use in conjugates.
17 cl, 3 dwg, 5 tbl, 34 ex
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