FIELD: medicine.
SUBSTANCE: invention relates to medicine, namely to rheumatology, and can be used to treat arthritis. For this purpose, the composition with a slow release is introduced, including lipid mass containing a mixture of the first phospholipid, the second phospholipid and cholesterol, in which the first phospholipid is DOPC, POPC, SPC or EPC, the second phospholipid is PEG-DSPE or DOPG and cholesterol is present in an amount of from 10 to 33 mol.% relative to the lipid mass; and one or more therapeutic agents for arthritis, wherein the sustained release composition is administered intra-articular.
EFFECT: invention makes it possible to reduce the signs and/or symptoms of arthritis in a subject, ensures prolonged pain relief with less frequent injections.
18 cl, 5 tbl, 11 dwg, 10 ex
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