METHODS TO REDUCE COMPLICATIONS FROM INTRA-ARTICULAR STEROID Russian patent published in 2023 - IPC A61K31/573 A61K31/661 A61K31/58 A61K9/127 A61P29/00 

FIELD: medicine.

SUBSTANCE: discloses a pharmaceutical composition for treating joint pain and reducing side effects caused by an intra-articular (IA) steroid in a subject, in which the pharmaceutical composition comprises: (a) a lipid mixture comprising 1,2-dioleoyl-sn- glycero-3-phosphatidylcholinel (DOPC), 1,2-dioleoyl-sn-glycero-3-phosphoglycerol (DOPG) and cholesterol in a molar ratio of 29.5% to 90%: 3% to 37.5%: 10 % to 33%; and (b) an effective amount IA of a steroid or a pharmaceutically acceptable salt thereof, which is selected from the group consisting of dexamethasone sodium phosphate, dexamethasone, betamethasone, betamethasone sodium phosphate, betamethasone acetate, betamethasone dipropioinate, betamethasone valerate, mometasone furonate, triamcinolone acetonide, triamcinolone hexacetonide, triamcinolone diacetate, methylprednisolone sodium succinate, methylprednisolone acetate, prednisolone tebutate, hydrocortisone acetate, alklomethasone dipropionate, halcinonide, fluocortolone, fluocinolone acetonide, or a combination thereof, and in which the IA steroid of the pharmaceutical composition is at a concentration of 15 mM to 40 mM. The group of inventions also discloses a method for treating joint pain and reducing side effects caused by an intra-articular (IA) steroid.

EFFECT: reducing the profile of side effects, such as reducing damage to cartilage and/or chondrocytes.

24 cl, 2 tbl, 4 dwg, 4 ex