FIELD: medicine.
SUBSTANCE: group of inventions relates to pharmaceutical compositions for the treatment of postoperative pain and methods of treating postoperative pain. A pharmaceutical composition for the treatment of postoperative pain contains a lipid complex, wherein the lipid complex contains an amide-type anaesthetic and at least one phospholipid, and the molar ratio of the amide-type anaesthetic to at least one phospholipid in the lipid complex is from 0.5:1 to 2:1 wherein the total amount of amide-type anaesthetic in the pharmaceutical composition is in the range from 300 mg to 600 mg. A pharmaceutical composition for treating pain in a subject in need of anaesthesia by means of a nerve block, by means of local anaesthesia or by means of infiltration anaesthesia, wherein the pharmaceutical composition contains the following: a lipid complex containing an amide-type anaesthetic and a neutral saturated phospholipid, wherein the neutral saturated phospholipid contains saturated fatty acids, with each saturated fatty acid independently contains a carbon chain with less than 18 carbon atoms; wherein the molar ratio of amide-type anaesthetic and neutral saturated phospholipid in the lipid complex ranges from 0.5:1 to 2:1; wherein the median diameter of the lipid complex is in the range from 5 mcm to 200 mcm and wherein the total amount of amide-type anaesthetic in the pharmaceutical composition is in the range from 300 mg to 600 mg. A method of treating postoperative pain in a subject requiring anaesthesia involves administering a pharmaceutical composition through a nerve block, through local anaesthesia, or through infiltration anaesthesia. A method of treating postoperative pain involves administering a pharmaceutical composition over a period of half an hour to three hours before or during surgery, wherein the pain reduction is at least 2 as measured by the NPRS on a scale from 0 to 10 over a period of at least 48 hours after the surgery.
EFFECT: above group of inventions provides an improved method of treating postoperative pain with less frequent dosing or lower doses to obtain an equivalent analgesic or anaesthetic effect and thus reduce the undesirable effects of the amide-type anaesthetic.
20 cl, 4 dwg, 3 ex
