FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to a composition for the specific binding of a heterotypic complex of keratin 7 to keratin 19, that can be used in medicine. Composition contains at least two targeted agents, the first targeted agent recognizing keratin 7 peptide and/or its fragment (-s) and one second targeted agent recognizes keratin 19 peptide and/or its fragment(s), where the first and second targeted agents are able to bind specifically and simultaneously with heterotypic keratin 7 complex with keratin 19 and/or its fragment (-s).
EFFECT: invention allows to diagnose and/or predict the effectiveness of treatment, evaluate the results of treatment, evaluate the recurrence of a malignant neoplastic disease, such as, for example, lung cancer, bladder cancer, esophageal cancer and ovarian cancer in a subject.
33 cl, 5 dwg, 13 ex, 8 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODY AND DRUG CONJUGATES AS A SPLICING MODULATOR AND METHODS OF THEIR USE | 2019 |
|
RU2799438C2 |
| CONTROL POINT INHIBITOR AND WHOLE-CELL MICROBACTERIA FOR USE IN TREATING ONCOLOGICAL DISEASE | 2014 |
|
RU2719934C2 |
| USE OF ANTI-PD-1 ANTIBODY IN PREPARATION OF MEDICINAL AGENT FOR TREATING SOLID TUMOURS | 2020 |
|
RU2825845C2 |
| ANTIBODIES USEFUL IN DIAGNOSING CANCER | 2018 |
|
RU2815883C1 |
| CANCER THERAPY BY COMBINED USE OF ONCOLYTIC SMALLPOX VACCINE VIRUS AND IMMUNE CONTROL POINT INHIBITOR, AND PHARMACEUTICAL COMPOSITION AND COMBINED DRUG FOR USE IN CANCER THERAPY | 2019 |
|
RU2788874C2 |
| MULTI-SPECIFIC ANTIBODIES INTENDED FOR USE IN TREATMENT OF URINARY TRACT NEOPLASM | 2017 |
|
RU2766358C2 |
| ANTIBODY-DRUG CONJUGATES CONTAINING HERBOXYDIENE-BASED SPLICING MODULATOR, AND METHODS OF USE THEREOF | 2019 |
|
RU2820607C2 |
| METHODS OF FORECASTING AND PREDICTION OF CANCER AND CONTROL ON THERAPY OF CANCER | 2006 |
|
RU2395090C2 |
| ANTI HUMAN INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN (IL1RAP) ANTIBODIES AND USES THEREOF | 2015 |
|
RU2710787C2 |
| CD43 ANTIBODIES AND USE THEREOF FOR TREATING CANCER | 2016 |
|
RU2694903C1 |
