ANTIBODY AND DRUG CONJUGATES AS A SPLICING MODULATOR AND METHODS OF THEIR USE Russian patent published in 2023 - IPC C07D405/00 C07K16/30 C07K7/00 C07K14/00 A61K47/68 A61K39/395 A61P35/00 

Abstract RU 2799438 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to new conjugates of antibodies with drugs, and can be used in medicine. The invention discloses conjugates of antibodies capable of binding to tumor antigens with fragment-drugs that are splicing modulators, wherein the conjugated fragments are interconnected via a linker.

EFFECT: invention may be used in the treatment of neoplastic disorders, in particular cancer.

52 cl, 10 ex, 27 tbl, 26 dwg

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RU 2 799 438 C2

Authors

Pazolli, Ermira

Buonamici, Silvia

Samarakoon, Thiwanka

Prajapati, Sudeep

Fishkin, Nathan

Palacino, James

Seiler, Michael

Zhu, Ping

Cook, Andrew

Smith, Peter

Liu, Xiang

Ellery, Shelby

Reynolds, Dominic

Yu, Lihua

Wu, Zhenhua

Peng, Shouyong

Calandra, Nicholas

Sheehan, Megan

Xiao, Yonghong

Dates

2023-07-05Published

2019-05-31Filed