FIELD: biotechnology.
SUBSTANCE: disclosed are antibodies and their antigen-binding fragments, which bind to claudin 6 (CLDN6), as well as conjugates of these antibodies for CLDN6 detection. Hybridomas producing said antibodies are also provided. Anti-CLDN6 antibodies are used to diagnose cancer and to determine expression of CLDN6 cancer cells.
EFFECT: invention provides binding to CLDN6 in FFPE tissues affected by cancer, with high specificity and low background activity.
28 cl, 6 dwg, 4 tbl, 9 ex
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