FIELD: immunology.
SUBSTANCE: antibodies or their antigen-binding fragments that immune-specifically bind to MUC16, conjugates, a chimeric antigen receptor, a T cell, and polynucleotides are proposed. Besides, a vector, cells, a pharmaceutical composition, and a method for the treatment of MUC16-positive cancer are considered.
EFFECT: present invention can be used in the therapy of MUC16-positive cancer.
40 cl, 109 dwg, 13 tbl, 4 ex
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