FIELD: chemistry; pharmacy.
SUBSTANCE: invention claims novel [1,2,4]triazolo[1,5-a]pyrimidine-2-ylurea derivatives of the general formula (1), or their pharmaceutically acceptable salts: [formula 1] 
, where Ar is optionally substituted phenyl group, dihydrobenzofuranyl or thiophenyl group. X is O. R is group of formula (2)-(6) 
or 
, where values of Cy and R4-R12 radicals are given in the claim, and medicine containing these compounds.
EFFECT: obtaining compounds with immunosuppressive or immune tolerance inducing effect, which can be applied in medicine.
14 cl, 16 tbl, 333 ex
| Title | Year | Author | Number |
|---|---|---|---|
| TRIAZOLOPYRIDINE COMPOUND AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER | 2010 |
|
RU2538963C2 |
| NEW TETRAHYDROPYRIMIDINE CONNECTION OR ITS SALT | 2015 |
|
RU2636310C1 |
| ENZYMES INHIBITION | 2013 |
|
RU2638537C2 |
| TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | 2012 |
|
RU2632870C2 |
| NEW 2-PYRIDINECARBOXAMIDE DERIVATIVES | 2004 |
|
RU2338744C2 |
| CONDENSED HETEROCYCLIC NITROGEN COMPOUNDS AND USING THEM AS INHIBITORS OF AMYLOID BETA PRODUCTION | 2010 |
|
RU2515976C2 |
| QUINOLINE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND ANTI-INFLAMMATORY AGENT | 1994 |
|
RU2132330C1 |
| HETEROCYCLIC AMIDE COMPOUND | 2014 |
|
RU2681941C2 |
| SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS PDE4 INHIBITORS | 2014 |
|
RU2802185C2 |
| COMPOUND OF THIAZOLIDINE OF PYRIDINE TYPE OR ITS SALT, HYPOGLYCAEMIC AGENT, ANTIGLYCATING AGENT AND PHARMACEUTICAL AGENT INHIBITING HYPERGLYCAEMIA, NONENZYMATIC GLYCATION AND ALDOSOREDUCTASE FOR PROPHYLAXIS AND TREATMENT OF DIABETES MELLITUS AND DIABETIC COMPLICATIONS | 1995 |
|
RU2125053C1 |
