THERAPEUTIC POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME Russian patent published in 2019 - IPC A61K9/51 A61K31/517 A61K47/34 A61K47/12 A61P35/00 B82B1/00 B82Y40/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the pharmaceutical industry. Disclosed is a therapeutic nanoparticle, comprising 10–25 wt. % (2-(3-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-5-yl)-N-(3-fluorophenyl)acetamide(AZD1152 hqpa), 5–20 wt. % pamoic acid and 55–85 wt. % diblock copolymer of poly(lactic acid)-polyethylene glycol, wherein said diblock copolymer, the polyethylene glycol block is 10–30 wt. % of said therapeutic nanoparticle. Also disclosed is a pharmaceutical composition for treating cancer, comprising a plurality of such therapeutic nanoparticles and one or more pharmaceutically acceptable excipients, diluents and / or carriers.

EFFECT: group of inventions increases the content of the drug substance encapsulated in the nanoparticle and provides an improved profile of its release.

14 cl, 13 ex, 21 tbl, 26 tbl