FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly oncology and aims at predicting the anti-oestrogen tamoxifen therapy effectiveness. An immune histochemical analysis of a tumour tissue is performed in the patients suffering luminal breast cancer, and a tumour tissue distribution pattern of oestrogen receptors alpha expression is described. Rs2228480 G/A polymorphism is stated in exon 8 of oestrogen receptors alpha (ERα) gene by real-time polymerase chain reaction. The state of regional lymph nodes is assessed. The tumour grade and the anti-oestrogen tamoxifen therapy effectiveness are calculated by formula. If P>0.5, the high anti-oestrogen tamoxifen therapy effectiveness is predicted. P<0.5 shows the low therapy effectiveness and a high probability of progression are predicted.
EFFECT: invention is very likely to predict of the therapy effectiveness and thereby applying an individual approach to choose a type of hormonal treatment in the patients suffering luminal breast cancer.
2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTING RISK OF BREAST CANCER PROGRESSION WITH UNDERLYING TAMOXIFEN TAKING INTO ACCOUNT EXPRESSION CHARACTERISTICS OF TUMOUR | 2023 |
|
RU2823488C1 |
| METHOD FOR PREDICTION OF FULL REGRESSION PROBABILITY DURING NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH THREE-TIMES NEGATIVE MOLECULAR-GENETIC SUBTYPE OF BREAST CANCER | 2016 |
|
RU2623118C1 |
| METHOD FOR PREDICTION OF DEGREE OF FULL REGRESSION PROBABILITY DURING NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH LUMINAL MOLECULAR-GENETIC SUBTYPE OF BREAST CANCER | 2016 |
|
RU2632112C1 |
| METHOD FOR PREDICTION OF LYMPHATIC CANCER SPREAD ACCOMPANIED BY INVASIVE NONSPECIFIC TRIPLE-NEGATIVE BREAST CANCER | 2014 |
|
RU2558860C1 |
| METHOD FOR PREDICTION OF ONSET OF LOCAL RECURRENCES IN SURGICAL SCARS IN UNICENTRIC INVASIVE DUCT BREAST CANCER IN PATIENTS WITH PRESERVED MENSTRUAL FUNCTION | 2012 |
|
RU2486518C1 |
| METHOD FOR PREDICTION OF HAEMATOGENOUS METASTASIS IN TRIPLE NEGATIVE INVASIVE NON-SPECIFIC BREAST CARCINOMA | 2014 |
|
RU2558863C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING DISTANT METASTASES IN PATIENTS WITH OPERABLE FORMS OF BREAST CANCER WITH METASTASES IN REGIONAL LYMPH NODES | 2020 |
|
RU2733697C1 |
| METHOD FOR PREDICTION OF OCCURRENCE OF LOCAL RECURRENCES IN POSTOPERATIVE PERIOD IN PATIENTS WITH LOCALLY ADVANCED BREAST CANCER | 2020 |
|
RU2734719C1 |
| APPLICATION OF 9-OCOACRIDINE-10-ACETIC ACID AND/OR ITS SALT COMBINED WITH ANTIESTROGEN AND/OR PROGESTIN FOR TREATMENT OF STROGEN-DEPENDENT TUMOURS, METHOD OF TREATMENT AND SETS | 2007 |
|
RU2346691C2 |
| METHODS OF TREATING CANCER | 2016 |
|
RU2737496C2 |
