METHOD FOR PRODUCING LIPOSOMAL FORM OF 2-ETHYL-6-METHYL-3-HYDROXYPYRIDINE SALT WITH NICOTIN ACID, USING IT FOR IMPROVING MICROCIRCULATION IN SKIN Russian patent published in 2019 - IPC A61K31/44 A61P17/00 A61K9/127 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to production of liposomal form of salt of 2-ethyl-6-methyl-3-hydroxypyridine with nicotinic acid. For this purpose, a mixture of lecithin and cholesterol is dissolved in ratio of 9:1 in chloroform followed by evaporation of the obtained solution at temperature of 37–40 °C and a phospholipid film is obtained, which is further hydrated at 37–40 °C in a phosphate buffer containing 2-ethyl-6-methyl-3-hydroxypyridine nicotinate. Weight ratio of the lipid phase to that of the phosphate buffer is 1:34–1:40. Obtained emulsion is treated at an ultrasonic unit. What is also presented is a method for using the liposomal form of 2-ethyl-6-methyl-3-hydroxypyridine salt with nicotinic acid for local application and using the liposomal form of 2-ethyl-6-methyl-3-hydroxypyridine salt with nicotinic acid for improving microcirculation in the skin.

EFFECT: group of inventions provides higher bioavailability of salt of 2-ethyl-6-methyl-3-hydroxypyridine with nicotinic acid in the transdermal route of using its liposomal form, additionally, the presence of one active ingredient and a minimum amount of excipients reduces the probability of developing allergic and other adverse reactions.

3 cl, 6 tbl, 2 ex