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2 763 011

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IPC

G09B23/28(2006-01-01)

A61K31/4425(2006-01-01)

A61P19/10(2006-01-01)

(21) (22)

Application

2021114187, 2021-05-19

(24)

Start date

2021-05-19

(22)

Actual filing date

2021-05-19

(45)

Published

2021-12-24

(72)

Inventor

Trunov Konstantin SergeevichSkachilova Sofiya YakovlevnaGudyrev Oleg SergeevichDanilenko Lyudmila MikhajlovnaPokrovskij Mikhail VladimirovichSimakina Ekaterina AleksandrovnaDanilenko Anton PavlovichShilova Elena VladimirovnaStefanova Marina SergeevnaYakushev Vladimir IvanovichGureev Vladimir VladimirovichMartynova Olga Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Natsionalnyj Issledovatelskij Universitet"

METHOD FOR THE CORRECTION OF OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES WITH 3-HYDROXY-2-ETHYL-6-METHYLPYRIDINIUM NICOTINATE IN EXPERIMENT Russian patent published in 2021 - IPC G09B23/28 A61K31/4425 A61P19/10

Abstract RU 2763011 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, the field of experimental pharmacology. A method for correcting osteoporosis and osteoporotic fractures with 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate in the experiment includes modeling osteoporosis using bilateral oophorectomy and osteoporotic fractures of the femur in female Wistar rats. As a means of correction, a compound of 3-hydroxy-2-ethyl-6-methylpyridinium nicotinate is used at a dose of 3.8 mg/kg, which is administered daily intragastrically to a laboratory animal twice a day, against the background of osteoporosis modeling for eight weeks, and in case of fractures - against the background of modeling osteoporosis for twelve weeks.

EFFECT: invention provides a significant correction of osteoporosis and osteoporotic fractures.

1 cl, 2 tbl, 1 ex

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RU 2 763 011 C1

Authors

Trunov Konstantin Sergeevich

Skachilova Sofiya Yakovlevna

Gudyrev Oleg Sergeevich

Danilenko Lyudmila Mikhajlovna

Pokrovskij Mikhail Vladimirovich

Simakina Ekaterina Aleksandrovna

Danilenko Anton Pavlovich

Shilova Elena Vladimirovna

Stefanova Marina Sergeevna

Yakushev Vladimir Ivanovich

Gureev Vladimir Vladimirovich

Martynova Olga Viktorovna

Dates

2021-12-24—Published

2021-05-19—Filed