FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to oncology, and can be used for treating pancreatic cancer (PCa). Invention relates to pharmaceutical compositions containing 3-(1-{3-[5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile or its hydrate hydrochloride and N-((S)-2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylamino)isonicotinamide, and using the combination of said substances for treating PCa.
EFFECT: using the inventions makes it possible to increase the PCA survival rates due to the higher anticancer activity of the combination.
6 cl
| Title |
Year |
Author |
Number |
| COMBINATION OF 6-OXO-1,6-DIHYDRO-PYRIDAZINE DERIVATIVE HAVING ANTICANCER ACTIVITY WITH QUINAZOLINE DERIVATIVE |
2015 |
- Bladt Fridkhelm
- Frize-Khamim Manya
|
RU2704120C2 |
| 6-OXO-1,6-DIHYDRO-PYRIDAZINE DERIVATIVE FOR USE IN TREATMENT OF HEPATOCELLULAR CARCINOMA (HCC) |
2013 |
- Frize-Khamim Manya
- Bladt Fridkhelm
|
RU2650679C2 |
| PHARMACEUTICAL PREPARATION |
2020 |
- Schoch Corinna
- Riehl Markus
- Hooff Gero
- Klemm Markus
- Schmidt Carsten
- Weigandt Markus
|
RU2822063C2 |
| PHARMACEUTICAL COMBINATIONS CONTAINING PYRIDO[4,3-d]PYRIMIDINE DERIVATIVES AS HSP90 INHIBITOR AND HER2 INHIBITOR |
2009 |
- Karlos Garsija-Ehcheverrija
- Mikaehl' Jensen
|
RU2532375C2 |
| FURO[3,2-B]- AND THIENO[3,2-B]PYRIDINE DERIVATIVES AS TBK1 AND IKKε INHIBITORS |
2013 |
- Eggenvajler Khans-Mikhael
- Kheltsemann Gyunter
- Dorsh Diter
|
RU2622034C2 |
| ACRYLANILIDE DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN PHARMACOLOGY |
2016 |
- Sy Tszyujtun
- Van Gan
- Yan Chzhikhe
- Tszyan Mejfen
- Syuj Benpo
- Chzhou Chentao
|
RU2742372C2 |
| METHODS FOR TREATMENT OF MALIGNANT TUMOR USING PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY |
2016 |
- Huck, Bayard R.
- Goodstal, Samantha M.
- Gimmi-Mckim, Claude
|
RU2765154C2 |
| COMBINATION, INCLUDING A) PYRIMIDYLAMINOBENZAMIDE AND B) KINASE Thr315lle INHIBITOR |
2007 |
|
RU2481840C2 |
| BENZIMIDAZOLE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND USE |
2017 |
- Wang Yiqian
- Wang Jiabing
- Ding Lieming
|
RU2779534C2 |
| 2-CARBOXAMIDE CYCLOAMINO UREA DERIVATIVES IN COMBINATION WITH HSP90 INHIBITORS FOR TREATING PROLIFERATIVE DISEASES |
2012 |
- Khuan Sichzhun
- Kvadt Korneliya
- Van Khoj-Tsin
- Fritch Kristin
- Shnell Kristian Rene
|
RU2624493C2 |
