PHARMACEUTICAL PREPARATION Russian patent published in 2024 - IPC A61K9/16 A61K9/20 A61K9/48 A61K31/506 A61K47/02 A61K47/26 A61P35/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutical industry. Invention proposes a solid preparation for treating cancer in the form for oral administration, containing 20–80 wt./wt.% micronised 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt thereof and an excipient selected from sugar, sugar alcohol and dicalcium phosphate; pharmaceutical preparation containing said solid preparation; method of producing said solid preparation by mixing an active agent and an excipient, followed by dry granulation of the obtained mixture; methods of producing a pharmaceutical preparation, which is a tablet or capsule; use of the pharmaceutical preparation in treating cancer.

EFFECT: group of inventions provides high content of the active agent in the preparation and improved bioavailability.

25 cl, 4 dwg, 2 tbl, 26 ex