FIELD: medicine.
SUBSTANCE: invention relates to medicine. Disclosed are compositions of biodegradable particles, comprising an effective amount of gliadin or one or more antigenic epitopes of gliadin encapsulated inside a particle core, wherein the particle has a negative zeta potential from -30 mV to -80 mV, and the diameter of said particle ranges from 200 to 2,000 nm. Also disclosed are methods for treating celiac disease by administering said compositions to a subject in need thereof.
EFFECT: compositions of the present invention are capable of inducing immunological tolerance to gliadin.
27 cl, 43 dwg, 24 ex
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