NEW COMPOUND ISOLATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR. SUBINTEGRUM, WITH A HIGH CONTENT OF ACTIVE INGREDIENT, COMPOSITION CONTAINING SAID COMPOUND FOR PREVENTING OR TREATING ALLERGIC DISEASE, INFLAMMATORY DISEASE, ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND USE THEREOF Russian patent published in 2019 - IPC C07H17/04 A61K31/7048 A61K31/357 A61K36/80 A61P11/06 A61P29/00 

Abstract RU 2685732 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel (3R, 5S, 5aS, 6R, 7S, 8R, 8aS)-8-chloro-8a-hydroxy-5-(((2S, 3R, 4S, 5S, 6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-3,6-methane-cyclopenta[e][1,3]dioxepin-7-yl-3,4-dihydroxybenzoate (KS534), represented by chemical formula (1). Invention also relates to a pharmaceutical composition and to a functional food product containing a therapeutically effective amount of a compound (KS534), for treating or preventing a disease caused by increased production of MUC5AC protein, increased level of eosinophils, pneumonia, mucus hypersecretion, immune response, high level of IL-6, TNF-alpha in bronchoalveolar lavage (BAL) or a high number of inflammatory cells.

(1).

EFFECT: technical result is obtaining a novel compound and a pharmaceutical composition based thereon, which can be used in medicine for treating an allergic disease, an inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD).

7 cl, 6 tbl, 14 dwg, 7 ex

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RU 2 685 732 C2

Authors

Li Ennam

Yu Chi-Sok

Sin Te-Khi

Yu Pen-Khvan

O Si-Yan

An Ken-Sop

Li Khen-Ke

Li Su Uj

Son Khek-Khvan

Sin In-Sik

Yu Khen Von

Dates

2019-04-23Published

2015-07-22Filed