FIELD: chemistry.
SUBSTANCE: invention relates to novel (3R, 5S, 5aS, 6R, 7S, 8R, 8aS)-8-chloro-8a-hydroxy-5-(((2S, 3R, 4S, 5S, 6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-3,6-methane-cyclopenta[e][1,3]dioxepin-7-yl-3,4-dihydroxybenzoate (KS534), represented by chemical formula (1). Invention also relates to a pharmaceutical composition and to a functional food product containing a therapeutically effective amount of a compound (KS534), for treating or preventing a disease caused by increased production of MUC5AC protein, increased level of eosinophils, pneumonia, mucus hypersecretion, immune response, high level of IL-6, TNF-alpha in bronchoalveolar lavage (BAL) or a high number of inflammatory cells.
(1).
EFFECT: technical result is obtaining a novel compound and a pharmaceutical composition based thereon, which can be used in medicine for treating an allergic disease, an inflammatory disease, asthma or chronic obstructive pulmonary disease (COPD).
7 cl, 6 tbl, 14 dwg, 7 ex
Title |
Year |
Author |
Number |
NOVEL COMPOUND (KS513) RECOVERED FROM PSEUDOLYSIMACHION ROTUNDUM VAR. SUBINTEGRUM, COMPOSITION CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT, FOR PREVENTING OR TREATING ALLERGIC DISEASE, INFLAMMATORY DISEASE, ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND USE THEREOF |
2016 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Yu Pen-Khvan
- O Si-Yan
- An Ken-Sop
- Li Khen-Ke
- Li Su Uj
- Son Khek-Khvan
- Yu Khen Von
|
RU2713906C2 |
COMPOSITION CONTAINING PURIFIED EXTRACT, EXTRACTED FROM Pseudolysimachion rotundum var.subintegrum CONTAINING GREAT AMOUNT OF ACTIVE COMPONENT,OR COMPOUNDS, EXTRACTED FROM IT, AS ACTIVE COMPONENT FOR PROPHYLAXIS OR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND THEREOF |
2014 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Lyu Pen-Khvan
- An Ken Sop
- O Se Lyan
- Li Khen Ke
- Sin In Sik
- Kim Du En
- Kvon Ok-Ken
- Son Khek Khvan
- Kim Syn Khen
- Li Suuj
|
RU2594061C1 |
PURIFIED EXTRACT (ATS2) SEPARATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR SUBINTEGRUM WITH HIGH CONTENT OF ACTIVE INGREDIENT, ITS PRODUCTION AND COMPOSITION CONTAINING THE ABOVE EXTRACT AS AN ACTIVE INGREDIENT TO PREVENT OR TREAT INFLAMMATION, ALLERGIES AND ASTHMA |
2013 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Lyu Pen-Khvan
- O Si-Yan
- An Ken-Sop
- Li Khenke
- Kvon Ok-Kyun
- Kim Tu-Yun
- Kim Chon-Khi
- Son Khek-Khvan
|
RU2674757C1 |
PURIFIED EXTRACT SEPARATED FROM PSEUDOLYSIMACHION ROTUNDUM VAR SUBINTEGRUM WITH HIGH CONTENT OF ACTIVE INGREDIENT, ITS PRODUCTION AND COMPOSITION CONTAINING THE ABOVE EXTRACT AS AN ACTIVE INGREDIENT TO PREVENT OR TREAT INFLAMMATION, ALLERGIES AND ASTHMA |
2013 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Lyu Pen-Khvan
- O Si-Yan
- An Ken-Sop
- Li Khenke
- Kvon Ok-Kyun
- Kim Tu-Yun
- Kim Chon-Khi
- Son Khek-Khvan
|
RU2606768C1 |
FUNCTIONAL FOOD PRODUCT CONTAINING PURIFIED EXTRACT AFTER SECONDARY FRACTIONATION (ATS2), OBTAINED FROM PSEUDOLYSIMACHION ROTUNDUM VAR SUBINTEGRUM WHITH HIGH CONTENT OF ACTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATION, ALLERGY AND ASTHMA |
2018 |
- Li Ennam
- Yu Chi-Sok
- Sin Te-Khi
- Lyu Pen-Khvan
- O Si-Yan
- An Ken-Sop
- Li Khenke
- Kvon Ok-Kyun
- Kim Tu-Yun
- Kim Chon-Khi
- Son Khek-Khvan
|
RU2682653C1 |
LACTOBACILLUS CRISPATUS KBL693 STRAIN AND ITS APPLICATION |
2019 |
- Ko, Vu Ri
- Li, Dzhun Chkhul
- Nam, Te Vuk
- Ko, Kvan Pe
- Yu, Khen Dzhu
- Yun, So En
- Son, Sok Chkhon
|
RU2791561C2 |
2-AMINO-BENZIMIDAZOLE DERIVATIVES AND USE THEREOF AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E-SYNTHASE INHIBITORS |
2015 |
- Kim Dzhesyn
- An Sokhen
- Chon Edzhin
- Park Donsik
- Yan Enin
- Li Dukhen
- Li Seen
- An Chije
- Kim Chondzhun
- Nam Kijyan
- Kan Sonkhi
- So Mindzhon
- So Muen
- So Chonche
- Khan Sondzhun
- Kim Chon Khvan
- Li Sanchkhol
- Chkhve Kakhi
- Li Yunmi
|
RU2732416C2 |
PYRIMIDINE INDOLE COMPOUNDS |
2010 |
|
RU2552999C2 |
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES MEDIATED BY REGULATORY T-CELLS |
2017 |
- Son, Sun Uk
- Li, Tak Gi
- Li, Khen Chu
|
RU2727900C2 |
COMPOSITION FOR ASTHMA PREVENTION OR TREATMENT CONTAINING MONOACETHYLDIACYL GLYCERINE COMPOUND AS ACTIVE INGREDIENT |
2014 |
- O Sej-Ryan
- An Kyun Sop
- Li Su Ui
- Sin In Sik
- Sin Na-Ne
- Li Te-Sok
- Kan Chonko
- Chon Yun-Sik
- Khan En-Khe
- Son Ki En
|
RU2636615C2 |