PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES MEDIATED BY REGULATORY T-CELLS Russian patent published in 2020 - IPC C12N5/783 C12N5/775 

Abstract RU 2727900 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to induction of CD4+ T-cell differentiation into regulatory T-cell and proliferation of regulatory T-cell induced by differentiation, as well as applications of mesenchymal stem cell overexpressing ICOSL (ligand of induced T-cell co-stimulator). Method involves treatment of CD4+ T-cell in vitro with mesenchymal stem cell overexpressing ICOSL. Mesenchymal stem cell, overexpressing ICOSL is used for treating an inflammatory disease or autoimmune disease and inducing differentiation of CD4+ T-cells into a regulatory T-cell and proliferation of regulatory T-cell induced by differentiation.

EFFECT: invention widens the range of equipment.

13 cl, 21 dwg, 15 ex

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RU 2 727 900 C2

Authors

Son, Sun Uk

Li, Tak Gi

Li, Khen Chu

Dates

2020-07-24Published

2017-02-24Filed