FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to oncology, and can be used for adaptive cellular immunotherapy. According to the invention a composition comprises CD4+ T lymphocytes and CD8+ T lymphocytes, modified by chimeric antigen receptor. According to the invention, the composition is used for the manufacture of a medicament for treating cancer. Method of manufacturing an adoptive immunotherapy composition comprising reproduction in vitro of the CD8+ T ymphocyte population, enriched with central memory T cells and CD4+ T lymphocyte populations, separately, and cell modification.
EFFECT: use of inventions allows enhancing the immune response due to the synergistic action of modified cells.
19 cl, 13 dwg, 6 ex
| Title |
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|
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|
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|
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|
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