PYRROLO[3,2-B]PYRIDINE DERIVATIVE USEFUL AS A MUSCARINE ACETYLCHOLINE RECEPTOR MODULATOR (mAChR)M1 (mAChR M1) Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to specific derivatives of pyrrolo[3,2-b]pyridine. Invention also relates to a heterocyclic compound of formula (IA), where R¹ is halogen, cyano, C_1-4alkyl or C_1-4alkoxy; R² is hydrogen; p is 1 or 2, and each R⁴ are independently selected from halogen, C_1-4alkyl, C_1-4alkoxy, C_1-4haloalkyl and C_1-4 haloalkoxy; to a heterocyclic compound of formula (IB), where R¹ is halogen, C_1-4alkyl or C_1-4alkoxy; R² is hydrogen; R^4a is hydrogen or halogen; R^4b is hydrogen, halogen, C_1-4alkyl, C_1-4alkoxy, C_1-4haloalkyl or C_1-4haloalkoxy; R^4c is hydrogen, halogen, C_1-4alkyl, C_1-4alkoxy or C_1-4haloalkyl; and R^4d is hydrogen or halogen, where at least one of R^4a, R^4b, R^4c and R^4d are not hydrogen, and not more than two of R^4a, R^4b, R^4c and R^4d are hydrogen; to a method for symptomatic treatment of cognitive disorders in dementia of Alzheimer's type (AD) and dementia with Levy bodies (DLB); to a pharmaceutical composition based on said compounds. (IA) (IB).

EFFECT: technical result is obtaining novel heterocyclic compounds which are muscarine acetylcholine receptor (mAChR) M1 modulators.

20 cl, 5 tbl