FIELD: medicine; ophthalmology.
SUBSTANCE: group of inventions is intended for the treatment of allergies. Compounds of formula I and their pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising such compounds and salts are provided. In another embodiment, the use of the said compounds and salts is provided for the inhibition of HPK1 kinase activity and for the treatment of cancer. A combination of these compounds and salts with another anti-cancer therapeutic or palliative agent for the treatment of cancer is also provided.
EFFECT: group of inventions provides new compounds of formula I and their pharmaceutically acceptable salts, which have inhibitory activity against HPK1 kinase, which can be used to treat or alleviate conditions associated with impaired normal cell proliferation, such as cancer.
19 cl, 5 tbl, 188 ex
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| BICYCLIC LACTAMS AND METHODS FOR USE THEREOF | 2016 |
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| DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS | 1989 |
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| DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | 2009 |
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| SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | 2019 |
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| PYRROLO-PYRROLE COMPOSITIONS AS ACTIVATORS OF PYRUVATE KINASE (PKR) | 2018 |
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| SUBSTITUTED CHROMANS | 2015 |
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RU2718060C2 |
