FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to oncology and can be used for increasing antitumour immune response. Methods according to the invention involve introduction of an antibody or its antigen-binding fragment, which are OX40 agonists, 1-methyltryptophan (1-MT) and an immunogenic composition containing a tumour antigen, wherein said tumour antigen is an HPV antigen.
EFFECT: use of inventions enables regressing the tumour by synergistic effect of the combination by inducing an immune response to the tumour antigen and increasing the CD8+ ratio T-cells and regulatory T-cells in the tumour.
25 cl, 5 dwg, 5 ex
| Title |
Year |
Author |
Number |
| BISPECIFIC ANTIBODIES TO CD25 AND Fc GAMMA-RECEPTOR FOR ELIMINATION OF TUMOR-SPECIFIC CELLS |
2017 |
- Kezada, Serkhio
- Peggs, Karl
- Arse Vargas, Frederik
|
RU2759970C2 |
| PROSTATE-ASSOCIATED ANTIGENS AND IMMUNOTHERAPEUTIC REGIMENS BASED ON VACCINES |
2013 |
- Binder, Joseph John
- Cho, Helen Kim
- Dermyer, Michael Robert
- Jooss, Karin Ute
|
RU2737765C2 |
| COMBINATION OF AN IMMUNE CHECKPOINT MODULATOR AND A COMPLEX CONTAINING A CELL-PENETRATING PEPTIDE, A CARGO MOLECULE, AND A TLR PEPTIDE AGONIST, FOR APPLICATION IN MEDICINE |
2017 |
- Derouazi Madiha
- Belnoue Elodie
|
RU2769314C1 |
| COMBINED THERAPY FOR TREATING CANCER USING A RECOMBINANT POXVIRUS EXPRESSING A TUMOR ANTIGEN AND AN ANTAGONIST OR AGONIST OF AN IMMUNE CONTROL POINT MOLECULE |
2015 |
- Foy Susan
- Mandl Stefanie
- Rountree Ryan
- Franzusoff Alex
|
RU2724433C2 |
| PROSTATE-ASSOCIATED ANTIGENS AND IMMUNOTHERAPY SCHEMES BASED ON VACCINES |
2013 |
- Binder Dzhozef Dzhon
- Chou Khelen Kim
- Dermier Majkl Robert
- Joss Karin Yute
- Pies Brajen Gregori
- Ten Dzhojs Tsi
- Tsaj Van To
|
RU2609651C2 |
| COMBINATION OF IMMUNE CHECKPOINT MODULATOR AND COMPLEX CONTAINING CELL-PENETRATING PEPTIDE, CARGO MOLECULE, AND TLR PEPTIDE AGONIST FOR MEDICAL USE |
2017 |
- Deruazi Madikha
- Belnu Elodi
|
RU2748378C2 |
| PREVENTIVE CANCER VACCINE |
2004 |
- Agadzhanjan Majkl G.
- Gochikjan Anait
|
RU2385163C2 |
| IMMUNOPROPHYLACTIC CANCER VACCINE |
2004 |
- Agadzhanjan, Majkl, G.
- Gochikjan, Anait
|
RU2556128C2 |
| VECTOR, CO-EXPRESSING MOLECULES FOR VACCINATION AND COSTIMULATORY MOLECULES |
2016 |
- Shrajber, Tejlor
- Fromm, Dzhordzh
|
RU2714157C2 |
| COMBINATION THERAPY FOR TREATING CANCER WITH POXVIRUS EXPRESSING TUMOUR ANTIGEN AND ANTAGONIST AND/OR AGONIST OF IMMUNE CHECKPOINT INHIBITOR |
2014 |
- Rauntri, Rajan
- Foj, Syuzan
- Mendl, Stefani
- Delker, Alen
|
RU2714142C2 |
