FIELD: biotechnology.
SUBSTANCE: invention refers to compositions and methods of treating cerebral cancer having mutations in a retinoblastoma (Rb) metabolic pathway, using oncolytic adenovirus containing a change in the Rb binding E1A region and isolating a motif inserted into the fibrillar protein Ad.
EFFECT: adenovirus is capable of destroying tumour cells without damaging cells of the metabolic pathway of wild type retinoblastoma.
30 cl, 10 dwg, 2 tbl, 2 ex
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