FIELD: biotechnology.
SUBSTANCE: described is a combination for treating a tumour, wherein the composition contains an oncolytic adenovirus, a CDK4/6 inhibitor and nutlin or a nutlin derivative, wherein the oncolytic adenovirus expresses the E1A12S protein and does not express the E1A13S protein. Also described is a method of treating a tumour, according to which an oncolytic adenovirus, a CDK4/6 inhibitor and nutlin or a nutlin derivative are administered to a subject, wherein the oncolytic adenovirus expresses the E1A12S protein and does not express the E1A13S protein.
EFFECT: invention extends the range of agents for treating tumours.
32 cl, 91 dwg, 1 tbl, 35 ex
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