FIELD: pharmaceuticals and medicine.
SUBSTANCE: 1 subject matter is a combination for treating a tumor with cells having YB-1 in the nucleus, comprising an oncolytic adenovirus and a CDK4/6 inhibitor, wherein the oncolytic adenovirus is XVir-N-31. Object 2 is a method of treating a tumor with cells having YB-1 in the nucleus, according to which the subject is administered an oncolytic adenovirus and a CDK4/6 inhibitor, wherein the oncolytic adenovirus is XVir-N-31.
EFFECT: increasing the effectiveness of tumor therapy and increasing virus replication.
18 cl, 34 dwg, 1 tbl, 24 ex
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