FIELD: medicine.
SUBSTANCE: invention concerns area of gene engineering, virology and medicine. Nominally replicating carcinolytic improved recombinant of the adenovirus includes the basic virus, the modified hTERT promotor and immune regulatory genes. The virus preferably expresses immunostimulating factor GM-CSF in tumoral cells. Also the modified promotor, the pharmaceutical composition including virus, the way of reception of virus and its application is revealed. The invention can be used in medicine for treatment of tumours.
EFFECT: development of a virus which preferably expresses immunostimulating factor GM-CSF in tumoral cells.
22 cl, 13 dwg, 2 tbl, 7 ex
| Title |
Year |
Author |
Number |
| GENETIC VECTOR Ad6/3-hTERT-GMCSF CONTAINING GENOMIC SEQUENCES OF RECOMBINANT ADENOVIRUS SEROTYPE 6, HUMAN TELOMERASE PROMOTER, HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR GENE, AS WELL AS FIBER PROTEIN GENE WITH INSERTION OF FIBER KNOB DOMAIN OF ADENOVIRUS SEROTYPE 3 WITH INCREASED TRANSDUCTION INTO TUMOR CELLS |
2023 |
- Yudin Sergej Mikhajlovich
- Keskinov Anton Arturovich
- Makarov Valentin Vladimirovich
- Fedoseeva Darya Mikhajlovna
- Nazarov Anton Sergeevich
- Netesov Sergej Viktorovich
- Romanenko Margarita Vladimirovna
- Osipov Ivan Dmitrievich
- Vasikhovskaya Valeriya Aleksandrovna
- Kutsejkin Sergej Sergeevich
|
RU2814581C1 |
| ADENOVIRAL VECTORS AND RELATED METHODS AND APPLICATIONS |
2009 |
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- Kanerva Anna
- Cherullo Vinchentso
- Pesonen Sari
|
RU2520823C2 |
| ONCOLYTIC ADENOVIRUS FOR TREATING CANCER, USING IT, AND PHARMACEUTICAL COMPOSITION CONTAINING IT |
2010 |
- Gedan Karrio Sonija
- Kaskal'O Pikeras Manel' Marija
- Alemani Bonastre Ramon
|
RU2536931C2 |
| EXTENDED ADOPTIVE CELL THERAPY |
2014 |
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- Vyakhya-Koskela, Markus
- Tyakhtinen, Siri
- Cherullo, Vinchentso
|
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| ADENOVIRUS WITH DIRECTED GENE EXPRESSION AND USE THEREOF |
2003 |
|
RU2393221C2 |
| CONDITIONALLY REPLICATING ADENOVIRUS |
2012 |
- Khirojyaki Mizuguchi
- Fuminori Sakunari
|
RU2642293C2 |
| ADENOVIRUS CONTAINING ALBUMIN-BINDING SITE |
2015 |
- Alemany Bonastre, Ramon
- Rojas Exposito, Luis Alfonso
|
RU2711371C2 |
| THERAPEUTIC COMPOSITIONS AND METHODS OF USING FOR TREATING CANCER |
2016 |
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- Galili, Uri
|
RU2720984C2 |
| ANTICANCER COMPOSITION CONTAINING A TUMOR-SPECIFIC ONCOLYTIC ADENOVIRUS AND AN IMMUNE RESPONSE CONTROL POINT INHIBITOR |
2018 |
|
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| RECOMBINANT ONCOLYTIC VIRUS, METHOD FOR ITS PRODUCTION, ITS APPLICATION AND THE DRUG ON ITS BASIS |
2020 |
|
RU2795230C1 |
