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2 690 536

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IPC

C08F8/42(2006-01-01)

C08F20/06(2006-01-01)

A61K31/78(2006-01-01)

(21) (22)

Application

2018142981, 2018-12-05

(24)

Start date

2018-12-05

(22)

Actual filing date

2018-12-05

(45)

Published

2019-06-04

(72)

Inventor

Smirnova Mariya SergeevnaSpiridonov Vasilij VladimirovichPozdnyakova Natalya VladimirovnaShibaeva Anna ValerevnaShevelev Aleksej BorisovichBiryukova Yuliya KonstantinovnaZylkova Marina ValerevnaBelyakova Alla VladimirovnaEpova Ekaterina YurevnaYaroslavov Aleksandr AnatolevichKuzmin Vladimir AleksandrovichOstrovskaya Larisa AnatolevnaKorman David BorisovichAbzaeva Klavdiya Alsykovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Biokhimicheskoj Fiziki Im. N.M. Emanuelya Rossijskoj Akademii Nauk Ran)

METHOD OF PRODUCING GOLD POLYACRYLATE EXHIBITING ANTI-TUMOR ACTIVITY Russian patent published in 2019 - IPC C08F8/42 C08F20/06 A61K31/78

Abstract RU 2690536 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing polyacrylate of gold. Method involves reaction of aqueous solutions of polyacrylic acid and hydrochloric acid. Prior to introduction into reaction, initial polyacrylic acid is subjected to flow dialysis and subsequent lyophilic drying. Aqueous solutions of hydrochloric acid and polyacrylic acid are reacted in amounts which provide 5–10-fold molar excess of monomer link (-CH₂-CHENCO-) relative to hydrochloric acid, wherein polyacrylic acid with average molecular weight in range of 1.6–140 kDa is used. Obtained product undergoes flow dialysis.

EFFECT: method enables to obtain highly soluble in water polyacrylate gold with high content of Au (III), responsible for its cytotoxic activity.

4 cl, 1 dwg, 1 tbl, 10 ex

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RU 2 690 536 C1

Authors

Smirnova Mariya Sergeevna

Spiridonov Vasilij Vladimirovich

Pozdnyakova Natalya Vladimirovna

Shibaeva Anna Valerevna

Shevelev Aleksej Borisovich

Biryukova Yuliya Konstantinovna

Zylkova Marina Valerevna

Belyakova Alla Vladimirovna

Epova Ekaterina Yurevna

Yaroslavov Aleksandr Anatolevich

Kuzmin Vladimir Aleksandrovich

Ostrovskaya Larisa Anatolevna

Korman David Borisovich

Abzaeva Klavdiya Alsykovna

Dates

2019-06-04—Published

2018-12-05—Filed