METHOD FOR QUANTITATIVE DETERMINATION OF DRUG SUBSTANCES OF A GROUP OF VASTATINES Russian patent published in 2019 - IPC G01N33/15 

FIELD: pharmaceuticals; physics.

SUBSTANCE: invention relates to pharmaceutical analysis, in particular to the analysis of materials using optical means. Method for quantitative determination of medicinal agents of a group of vastatines involves dissolving the analysed sample at room temperature and stirring until complete dissolution, treatment of an aliquot part of the prepared solution with chemical reagents followed by photoelectrocolorimetry of the obtained coloured solutions, quantitative determination of drug substances of the group of vastatines by calibration graphs, wherein the analysed sample is dissolved in methanol, an aliquot portion of the prepared solution is treated with a methanolic solution of nickel sulphate in concentrated hydrochloric acid at room temperature, the separated coloured precipitate is extracted with chloroform, dried over anhydrous sodium sulphate and photoelectrocolorimetry at wave length 590 nm.

EFFECT: what is offered is a method for quantitative determination of drug substances of a group of vastatines.

1 cl, 7 dwg, 1 ex