TRIAZINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES Russian patent published in 2019 - IPC C07D251/22 C07D401/04 C07D401/10 C07D401/12 C07D403/10 C07D405/12 C07D471/10 A61K31/53 A61P9/10 A61P19/02 A61P25/28 A61P27/06 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula [I], or a pharmaceutically acceptable salt thereof. In formula [I] X is CH or N, ring Cy is formula

or formula

,

R⁵ is (1) halogen, (2) hydroxy, (3) C_1-6 alkylsulphanyl, (4) C_1-6 alkyl (said C_1-6 alkyl is optionally substituted with 1, 2 or 3 substitutes selected from a group consisting of halogen, C₆ aryl and C_1-6 alkoxy), (5) C_3-7 cycloalkyl, (6) -OR^d or (7) formula

, m1 is equal to 0, 1, 2 or 3 and, when m1 is equal to 2 or 3, each R⁵ is selected independently from each other. Other radical values are presented in the patent claim. Invention also relates to individual compounds, to a pharmaceutical composition, to an mPGES-1 inhibitor, to a therapeutic or prophylactic agent, to a mPGES-1 inhibition method, to a method of treating or preventing, to use of the compound.

EFFECT: technical result is obtaining novel compounds of formula [I], having PGES-1 inhibitor properties.

19 cl, 1 dwg, 64 tbl, 34 ex