TRIAZINONE COMPOUND AND T-TYPE CALCIUM CHANNELS INHIBITOR Russian patent published in 2018 - IPC C07D251/42 C07D401/04 C07D401/06 C07D401/12 C07D401/14 C07D403/04 C07D403/06 C07D403/12 C07D403/14 C07D405/14 C07D409/06 C07D409/14 C07D413/04 C07D417/12 C07D417/14 A61K31/53 A61P25/04 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of the formula

where R¹ represents a hydrogen atom, C_1-6 alkyl group, C_1-6 alkoxy group, di-C_1-6 alkylamino group; each of L¹ and L² independently represents a single bond, NR², O, S or a C_1-6alkylene group; B is a C_3-11 cycloalkylene group, a C_3-11 cycloalkenylene group, a 3 to 11-membered heterocyclylene group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C_6-10 arylene group, a 5 to 10 membered heteroarylene group containing 1 to 5 hetero atoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C_1-6 alkylene group or a C_2-6 alkenylene group; A is a C_1-6 alkyl group, a C_3-11 cycloalkyl group, a C_3-11 cycloalkenyl group, a 3 to 11-membered heterocyclyl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C_6-10 aryl group or a 5 to 10 membered heteroaryl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom); L³ is a C_1-6 alkylene group; D is a C_3-11 cycloalkyl group, a C_3-11 cycloalkenyl group, a 3 to 11-membered heterocyclyl group containing 1 to 5 heteroatoms as ring-forming atoms (the heteroatom is a nitrogen atom, an oxygen atom or a sulfur atom), a C_6-10 aryl group or a 5 to 10 membered heteroaryl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom); the values of the remaining substituents are indicated in the claims. The invention also relates to a T-type calcium channel inhibitor, a prophylactic agent, a therapeutic agent for neuropathic pain, a medicament.

EFFECT: new compounds of the formula having inhibitory activity against T-type calcium channels are obtained.

37 cl, 43 tbl, 876 ex