FIELD: medicine.
SUBSTANCE: invention relates to peptides which can efficiently and specifically reactivate mutant p53 proteins. In particular, peptides which reactivate the mutant p53 protein, which can restore native folding of wild-type p53 protein and, hence, activity of tumor suppressors with respect to mutant p53 protein are disclosed.
EFFECT: such peptides can be suitable for treating various conditions and diseases in which p53 protein is mutated.
17 cl, 10 tbl, 12 ex, 21 dwg
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2014 |
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