FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions refers to tuberculosis treatment. Oral fixed-dose pharmaceutical composition in the form of a dispersible tablet which dissolves in the liquid prior to administration includes isoniazid-containing granules and at least one intragranular excipient which contains microcrystalline cellulose, sodium starch glycolate, povidone or mixtures thereof; granules containing rifapentine and at least one intragranular excipient which contains microcrystalline cellulose, sodium ascorbate, sodium starch glycolate, hydroxypropyl cellulose, gelatized starch or mixtures thereof; and at least one extragranular excipient which contains sodium ascorbate. Also disclosed is a method for preparing an oral pharmaceutical composition.
EFFECT: group of inventions provides a chemically stable oral pharmaceutical composition.
10 cl, 2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-TUBERCULOSIS STABLE PHARMACEUTICAL COMPOSITION IN A FORM OF A COATED TABLET COMPRISING GRANULES OF ISONIAZID AND GRANULES OF RIFAPENTINE AND ITS PROCESS OF PREPARATION | 2014 |
|
RU2682178C2 |
| SOLID FORMULATIONS OF OSPEMIFENE | 2005 |
|
RU2675624C2 |
| ANTITUBERCULAR COMPOSITION COMPRISING RIFAMPICIN, ISONIAZID, ETHAMBUTOL AND PYRAZINAMIDE AND PROCESS FOR PREPARATION THEREOF | 2014 |
|
RU2672879C2 |
| NEW COMPOSITION OF LAPATINIB AS A SOLID DOSAGE FORM FOR ORAL USE AND A METHOD OF ITS MANUFACTURE | 2019 |
|
RU2821950C2 |
| SOLID PREPARATIVE FORMS OF OSPEMIFENE | 2005 |
|
RU2423113C2 |
| HIGH DOSAGE STRENGTH TABLETS OF RUCAPARIB | 2015 |
|
RU2705156C2 |
| PHARMACEUTICAL COMPOSITIONS WITH CDC7 INHIBITOR | 2019 |
|
RU2810927C2 |
| ORAL COMPOSITIONS OF CARDIAC SARCOMERE INHIBITORS | 2020 |
|
RU2823999C2 |
| PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY | 2009 |
|
RU2485947C2 |
| GLUCOSAMINE PROLONGED RELEASE DOSAGE FORM | 2011 |
|
RU2521231C2 |
