PYRIDINE CARBOXAMIDE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF Russian patent published in 2019 - IPC C07D405/14 A61K31/4545 A61P9/00 A61P13/12 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to pyridine carboxamide derivatives of general formula (I), their pharmaceutically acceptable salts, where R¹ is C₁-C₆ alkyl, where said C₁-C₆ alkyl is optionally further substituted with one or more halogen; R² is hydrogen; R³ is ; R⁴ and R⁵ each is independently selected from a group consisting of hydrogen, C₁-C₆ alkyl; n equals 0, 1 or 2. Invention also relates to a method for preparing said compounds, to a pharmaceutical composition which inhibits an external medullary potassium renal channel (ROMK) based on said compounds.

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EFFECT: technical result is obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating and/or preventing renal diseases, hypertension and heart failure.

18 cl, 5 dwg, 5 tbl, 4 ex