TWO-LEVEL MICROGRANULATED FORM OF THERAPEUTICAL PEPTIDE FOR ORAL ADMINISTRATION AND METHOD FOR PREPARING IT Russian patent published in 2019 - IPC A61K9/14 A61K38/02 

FIELD: pharmacology.

SUBSTANCE: group of inventions relates to pharmacology and includes a micro granulated form of a therapeutic peptide and a method for production thereof. Two-level microgranular form of the therapeutic peptide for oral administration consists of first-level carriers – porous calcium carbonate kernels with size of 1–5 mcm with average pore size of 10–40 nm, having a single-layer alginate coating and containing on surface and in pores a therapeutic peptide with high isotopic amount of 70–90 mcg/mg, located in the volume of the second level carrier – a porous alginate-calcium matrix with average pore size of 5–200 nm, containing peptidase inhibitor – ovomucoid and forming target microgranules of 800–900 mcm size. Inclusion of peptide and ovomucoid in them is 8–35 mcg/mg and 80–100 mcg/mg, respectively.

EFFECT: obtaining an easily digestible micro-granular form of the therapeutic peptide for oral administration with high and controlled content of the target object using a lower power-consuming, environmentally friendly and high output of the end product.

2 cl, 5 ex