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2 695 326

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IPC

A61K31/5685(2006-01-01)

A61P35/00(2006-01-01)

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Application

2018120752, 2018-06-05

(24)

Start date

2018-06-05

(22)

Actual filing date

2018-06-05

(45)

Published

2019-07-23

(72)

Inventor

Ipatova Olga MikhajlovnaMedvedeva Natalya VelorikovnaSanzhakov Maksim AleksandrovichKostryukova Lyubov ViktorovnaKorotkevich Evgeniya IgorevnaKudinov Vasilij AndreevichTikhonova Elena GeorgievnaKhudoklinova Yuliya Yurevna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Biomeditsinskoj Khimii Imeni V.N. Orekhovicha"

ANTITUMOUR AGENT FOR TREATING PROSTATE CANCER IN THE FORM OF SACHET Russian patent published in 2019 - IPC A61K31/5685 A61P35/00

Abstract RU 2695326 C1

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to medical chemistry and pharmacology, and concerns an antitumour agent for treating prostate cancer in form of 2-sachet'-{[(E)-3β-hydroxy-androst-5-en-17-ylidene]methyl}-4',5'-dihydro-1',3'-oxazole, modified with oleic acid to obtain a pharmaceutical substance – (3S,10R,13S,E)-17-((4,5-dihydrooxazol-2-yl)methylene)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl oleate, wherein the antitumour agent additionally contains phospholipid and maltose in the following ratio of components: pharmaceutical substance: phospholipid: maltose 1:10:39.

EFFECT: use of the invention enables higher clinical effectiveness with reduced dose and reduced toxic effect on healthy tissues.

1 cl, 4 dwg, 5 tbl, 6 ex

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RU 2 695 326 C1

Authors

Ipatova Olga Mikhajlovna

Medvedeva Natalya Velorikovna

Sanzhakov Maksim Aleksandrovich

Kostryukova Lyubov Viktorovna

Korotkevich Evgeniya Igorevna

Kudinov Vasilij Andreevich

Tikhonova Elena Georgievna

Khudoklinova Yuliya Yurevna

Dates

2019-07-23—Published

2018-06-05—Filed