FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine and concerns a ligand characterized by asialoglycoprotein receptor affinity and intended for delivering an antitumour compound used in therapy of hepatocellular carcinoma, which is a N-acetyl galactosamine derivative. Group of inventions also relates to a compound for therapy of hepatocellular carcinoma, which is a conjugate of said ligand with an antitumour compound; method of obtaining said compound by reacting [3+2] azide-alkyne cycloadaptation.
EFFECT: group of inventions provides treating hepatocellular carcinoma.
27 cl, 15 ex, 3 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CONJUGATES OF MONOMETHYL AURISTATIN E WITH ASIALOGLYCOPROTEIN RECEPTOR LIGANDS FOR TARGETED TRANSPORT INTO TUMOR CELLS OF LIVER | 2022 |
|
RU2809635C1 |
| CONJUGATE OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITOR WITH ASIALOGLYCOPROTEIN RECEPTOR LIGAND | 2022 |
|
RU2816947C2 |
| PEPTIDE AGENT COMPRISING A PSMA-BINDING LIGAND BASED ON A UREA DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF FOR PREPARING A CONJUGATE WITH A DRUG AND DIAGNOSTIC AGENT | 2018 |
|
RU2697519C1 |
| LIGANDS, TROPIC TO PROSTATIC SPECIFIC MEMBRANE ANTIGEN AND USE THEREOF FOR OBTAINING DOUBLE CONJUGATES WITH THERAPEUTIC AGENTS BASED THEREON FOR COMBINED THERAPY OF PSMA EXPRESSING TUMOURS | 2023 |
|
RU2841078C1 |
| MONOMETHYL AURISTATIN E CONJUGATE FOR PREPARING A COMPOSITION FOR TREATING PROSTATE CANCER | 2019 |
|
RU2729192C1 |
| METHODS FOR GLYCOSGINOPHYLIPIDS OBTAINING AND THEIR APPLICATION | 2012 |
|
RU2636587C2 |
| PEPTIDE COMPOUND CAPABLE OF BINDING WITH PSMA, METHOD FOR PRODUCTION AND USE THEREOF | 2021 |
|
RU2823164C2 |
| CONJUGATE OF A FLUORESCENT DYE WITH A PEPTIDE SUBSTANCE WHICH CONTAINS A PSMA-BINDING LIGAND BASED ON A UREA DERIVATIVE FOR VISUALIZING CELLS EXPRESSING PSMA, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF | 2019 |
|
RU2713151C1 |
| LOW MOLECULAR WEIGHT LIGANDS OF ASIALOGLYCOPROTEIN RECEPTOR BASED ON QUINOLINE-4-CARBOXYLIC ACID | 2020 |
|
RU2769859C1 |
| METHOD OF OBTAINING HYDROCHLORIDE OF BETA-6-AMINOHEXYLGLICOSIDE-ACETYL NURAMOIL-L-ALANYL-D-ISOGLUTAMINE | 0 |
|
SU1558927A1 |
