LOW-MOLECULAR CONJUGATES OF ANTITUMOUR AGENTS AND HIGHLY SELECTIVE LIGANDS OF ASIALOGLYCOPROTEIN RECEPTOR FOR THERAPY OF ONCOLOGICAL LIVER PATHOLOGIES Russian patent published in 2019 - IPC A61K31/351 A61K31/41 A61P35/00 

Abstract RU 2696096 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and concerns a ligand characterized by asialoglycoprotein receptor affinity and intended for delivering an antitumour compound used in therapy of hepatocellular carcinoma, which is a N-acetyl galactosamine derivative. Group of inventions also relates to a compound for therapy of hepatocellular carcinoma, which is a conjugate of said ligand with an antitumour compound; method of obtaining said compound by reacting [3+2] azide-alkyne cycloadaptation.

EFFECT: group of inventions provides treating hepatocellular carcinoma.

27 cl, 15 ex, 3 dwg, 1 tbl

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RU 2 696 096 C2

Authors

Petrov Rostislav Aleksandrovich

Petrov Stanislav Aleksandrovich

Yamansarov Emil Yulaevich

Maklakova Svetlana Yurevna

Saltykova Irina Vladimirovna

Beloglazkina Elena Kimovna

Mazhuga Aleksandr Georgievich

Dates

2019-07-31Published

2017-12-07Filed