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2 696 096

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IPC

A61K31/351(2006-01-01)

A61K31/41(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2017142686, 2017-12-07

(24)

Start date

2017-12-07

(22)

Actual filing date

2017-12-07

(45)

Published

2019-07-31

(72)

Inventor

Petrov Rostislav AleksandrovichPetrov Stanislav AleksandrovichYamansarov Emil YulaevichMaklakova Svetlana YurevnaSaltykova Irina VladimirovnaBeloglazkina Elena KimovnaMazhuga Aleksandr Georgievich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennyj Universitet Imeni M.V. Lomonosova"

LOW-MOLECULAR CONJUGATES OF ANTITUMOUR AGENTS AND HIGHLY SELECTIVE LIGANDS OF ASIALOGLYCOPROTEIN RECEPTOR FOR THERAPY OF ONCOLOGICAL LIVER PATHOLOGIES Russian patent published in 2019 - IPC A61K31/351 A61K31/41 A61P35/00

Abstract RU 2696096 C2

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and concerns a ligand characterized by asialoglycoprotein receptor affinity and intended for delivering an antitumour compound used in therapy of hepatocellular carcinoma, which is a N-acetyl galactosamine derivative. Group of inventions also relates to a compound for therapy of hepatocellular carcinoma, which is a conjugate of said ligand with an antitumour compound; method of obtaining said compound by reacting [3+2] azide-alkyne cycloadaptation.

EFFECT: group of inventions provides treating hepatocellular carcinoma.

27 cl, 15 ex, 3 dwg, 1 tbl

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RU 2 696 096 C2

Authors

Petrov Rostislav Aleksandrovich

Petrov Stanislav Aleksandrovich

Yamansarov Emil Yulaevich

Maklakova Svetlana Yurevna

Saltykova Irina Vladimirovna

Beloglazkina Elena Kimovna

Mazhuga Aleksandr Georgievich

Dates

2019-07-31—Published

2017-12-07—Filed